| Cancer-Fighting Immune Cells Could Soon Be Engineered Inside Our Bodies May 27th 2025, 16:00 by msmash Researchers are developing techniques to genetically modify cancer-fighting immune cells directly inside patients rather than in expensive laboratory facilities, potentially making CAR-T therapy accessible to far more people. Current CAR-T treatments require removing a patient's T cells, shipping them to specialized facilities for genetic engineering, then returning them weeks later at costs around $500,000 per dose. The new "in vivo" approaches use viral vectors or RNA-loaded nanoparticles to deliver genetic instructions directly to T cells circulating in the bloodstream, which could reduce costs by an order of magnitude. Companies including Capstan Therapeutics, co-founded by Nobel laureates, and AstraZeneca-backed EsoBiotec have launched early human trials. While only about 200 US centers currently offer traditional CAR-T therapy, the approach could make the powerful treatment available on demand like conventional drugs. Read more of this story at Slashdot. | | Adidas Warns of Data Breach After Customer Service Provider Hack May 27th 2025, 15:20 by msmash German sportswear giant Adidas disclosed a data breach after attackers hacked a customer service provider and stole some customers' data. From a report: "adidas recently became aware that an unauthorized external party obtained certain consumer data through a third-party customer service provider," the company said. "We immediately took steps to contain the incident and launched a comprehensive investigation, collaborating with leading information security experts." Adidas added that the stolen information did not include the affected customers' payment-related information or passwords, as the threat actors behind the breach only gained access to contact. The company has also notified the relevant authorities regarding this security incident and will alert those affected by the data breach. Read more of this story at Slashdot. | | Everybody's Mad About Uno May 27th 2025, 14:40 by msmash More than 50 years after its debut, Uno has achieved unprecedented popularity among adults, but its resurgence is creating problems and confusions as players disagree on fundamental rules. WSJ, in a fun story [non-paywalled source]: Think politics divides? Try mixing competitors with different views on stacking "action" cards, or getting everyone to agree on the true power of the Wild card. And nobody can seem to decide whether staples of the game of their youth -- like mandating players yell "Uno!" when they have one card left -- are socially acceptable at a bar with strangers. Mattel has responded by actively settling rule debates on social media, definitively stating that stacking Draw 2 cards is prohibited, while simultaneously embracing the game's divisive nature through marketing campaigns. The company's "Show 'Em No Mercy" variant, featuring more aggressive rules, became the second-best-selling card game in the United States last year according to research firm Circana, trailing only classic Uno itself.   Read more of this story at Slashdot. | | Browser Company Abandons Arc for AI-Powered Successor May 27th 2025, 14:02 by msmash The Browser Company has ceased the active development of its Arc browser to focus on Dia, a new AI-powered browser currently in alpha testing, the company said Tuesday. In a lengthy letter to users, CEO Josh Miller said the startup should have stopped working on Arc "a year earlier," noting data showing the browser suffered from a "novelty tax" problem where users found it too different to adopt widely. Arc struggled with low feature adoption -- only 5.52% of daily active users regularly used multiple Spaces, while 4.17% used Live Folders. The company will continue maintenance updates for Arc but won't add new features. Arc also won't open-source the browser because it relies on proprietary infrastructure called ADK (Arc Development Kit) that remains core to the company's value. Read more of this story at Slashdot. | | 25% iPhone Tariff Insufficient To Drive US Production Shift, Morgan Stanley Says May 27th 2025, 12:07 by msmash President Trump's threat of a 25% tariff on smartphone imports including iPhones would not provide enough economic incentive for Apple to relocate US-bound iPhone production to domestic facilities, according to a new Morgan Stanley note viewed by Slashdot. The tariff threat, announced Friday via social media, appeared to target Apple's recent shift of iPhone production from China to India through its contract manufacturing partners. Morgan Stanley analysts estimate that establishing US iPhone production would require a minimum of two years and several billion dollars to build multiple greenfield assembly facilities, with a trained workforce exceeding 100,000 workers during peak seasons. More significantly, the firm calculates that a US-produced iPhone would cost 35% more than current China or India production, primarily due to higher labor costs and the need to import 25% of iPhone components from China under existing 30% tariffs. By contrast, Apple could offset a 25% import tariff by raising global iPhone prices just 4-6%, making domestic production economically unviable. Read more of this story at Slashdot. | | What Do People Want? May 27th 2025, 10:00 by msmash Abstract of a paper on NBER: We elicited over a million stated preference choices over 126 dimensions or "aspects" of well-being from a sample of 3,358 respondents on Amazon's Mechanical Turk (MTurk). Our surveys also collected self-reported well-being (SWB) questions about respondents' current levels of the aspects of well-being. From the stated preference data, we estimate relative log marginal utilities per point on our 0-100 response scale for each aspect. We validate these estimates by comparing them to alternative methods for estimating preferences. Our findings provide empirical evidence that both complements and challenges philosophical perspectives on human desires and values. Our results support Aristotelian notions of eudaimonia through family relationships and Maslow's emphasis on basic security needs, yet also suggest that contemporary theories of well-being may overemphasize abstract concepts such as happiness and life satisfaction, while undervaluing concrete aspects such as family well-being, financial security, and health, that respondents place the highest marginal utilities on. We document substantial heterogeneity in preferences across respondents within (but not between) demographic groups, with current SWB levels explaining a significant portion of the variation. Read more of this story at Slashdot. | | Europe Warns Giant E-tailer To Stop Cheating Consumers or Face Its Wrath May 27th 2025, 08:00 by msmash The European Commission warned Chinese e-tailer SHEIN on Monday that it must address multiple consumer law violations or face fines across EU member states. Regulators found SHEIN's website displayed fake discounts not based on actual prior prices, used pressure-selling tactics with false purchase deadlines, provided misleading information about consumer return rights, made deceptive sustainability claims, and hid contact details from customers. SHEIN has one month to respond to the findings and propose corrective measures, adding regulatory pressure to a company already facing US tariff challenges despite generating an estimated $38 billion in revenue last year. Read more of this story at Slashdot. | | Immigration Is the Only Thing Propping Up California's Population May 27th 2025, 06:13 by msmash California's population grew 0.6% in 2024, adding nearly 250,000 residents to reach 39.43 million, according to Census Bureau estimates. The growth came entirely from a rebound in international immigration, which surged to over 300,000 people after plunging to 44,000 during the pandemic's worst year. Without immigration, the state would have shrunk significantly as domestic migration remained negative. The H-1B visa program alone brought nearly 79,000 skilled workers to California in 2024. Since 2010, California has added 2.7 million immigrants, with half coming from Asia and slightly more than a third from Latin America. The immigration-dependent growth model puts California at particular risk from potential federal policy changes, as more than a quarter of its population is foreign-born -- the highest share nationwide. Read more of this story at Slashdot. | |
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