| Will 2024 Bring a 'Major Turning Point' in US Health Care? Jan 1st 2024, 02:08, by EditorDavid "This year has been a major turning point in American health care," reports USA Today, "and patients can anticipate several major developments in the new year," including the beginning of a CRISPR "revolution" and "a new reckoning with drug prices that could change the landscape of the U.S. health care system for decades to come." Health care officials expect 2024 to bring a wave of innovation and change in medicine, treatment and public health... Many think 2024 could be the year more people have the tools to follow through on New Year's resolutions about weight loss. If they can afford them and manage to stick with them, people can turn to a new generation of remarkably effective weight-loss drugs, also called GLP-1s, which offer the potential for substantial weight loss... In 2023, mental health issues became among the nation's most deadly, costly and pervasive health crises... The dearth of remedies has also paved the way for an unsuspecting class of drugs: psychedelics. MDMA, a party drug commonly known as "ecstasy," could win approval for legal distribution in 2024, as a treatment for post-traumatic stress disorder. Another psychedelic, a ketamine derivative eskatemine, sold as Spravato, was approved in 2019 to treat depression, but it is being treated like a conventional therapy that must be dosed regularly, not like a psychedelic that provides a long-lasting learning experience, said Matthew Johnson, an expert in psychedelics at Johns Hopkins University. MDMA (midomafetamine capsules) would be different, as the first true psychedelic to win FDA approval. In a late-stage trial of patients with moderate or severe post-traumatic stress disorder, close to 90% showed clinically significant improvements four months after three treatments with MDMA and more than 70% no longer met the criteria for having the disorder, which represented "really impressive results," according to Matthew Johnson, an expert in psychedelics at Johns Hopkins University in Maryland. Psilocybin, known colloquially as "magic mushrooms," is also working its way through the federal approval process, but it likely won't come up before officials for another year, Johnson said. Psychedelics are something to keep an eye on in the future, as they're being used to treat an array of mental health issues: eskatimine for depression, MDMA for PTSD and psilocybin for addiction. Johnson said his research suggests that psychedelics will probably have a generalizable benefit across many mental health challenges in the years to come. 2024 will also be the first year America's drug-makers face new limits on how much they can increase prices for drugs covered by the federal health insurance program Medicare.   Read more of this story at Slashdot. | | Since the Demise of Atom, 'Pulsar' Offers an Alternative Code Editor Jan 1st 2024, 01:08, by EditorDavid On December 15 GitHub declared end-of-life for its "hackable text editor" Atom. But Long-time Slashdot reader BrendaEM wants to remind everyone that after the announcement of Atom's sunset, "the community came together to keep Atom alive." First there was the longstanding fork Atom-Community. But "due to differences in long-term goals for the editor, a new version was born: Pulsar." From the Pulsar web site: Pulsar [sometimes referred to as Pulsar-Edit] aims to not only reach feature parity with the original Atom, but to bring Pulsar into the 21st century by updating the underlying architecture, and supporting modern features. With many new features on the roadmap, once Pulsar is stable, it will be a true, Community-Based, Hackable, Text Editor. "Of course, the user interface is much of the same," writes the blog Its FOSS, and it's cross-platform (supporting Linux, macOS, and Windows). "The essentials seem to be there with the documentation, packages, and features like the ability to install packages from Git repositories..." Read more of this story at Slashdot. | | Navajo Nation President Asks NASA to Delay Moon Launch Over Possible Human Remains Dec 31st 2023, 23:42, by EditorDavid "Navajo Nation President Buu Nygren has asked NASA to delay a scheduled launch to the Moon that could include cremated remains," reports Arizona Public Radio station KNAU: Nygren says he recently learned of the January 8 launch of the Vulcan Centaur carrying the Peregrine Mission One. The lander will carry some payloads from a company known to provide memorial services by shipping human cremated remains to the Moon. Nygren wants the launch delayed and the tribe consulted immediately. He noted the Moon is sacred to numerous Indigenous cultures and that depositing human remains on it is "tantamount to desecration." NASA previously came under fire after the ashes of former geologist and planetary scientist Eugene Shoemaker were sent to the Moon in 1998. Then-Navajo Nation President Albert Hale said the action was a gross insensitivity to the beliefs of many Native Americans. NASA later apologized and promised to consult with tribes before authorizing any similar missions in the future. Read more of this story at Slashdot. | | The Wealthiest Californians are Leaving the State, Hurting the Economy, Statistics Confirm Dec 31st 2023, 22:42, by EditorDavid "For several years, thousands more high-earning, well-educated workers have left California than have moved in," reports the Los Angeles Times: Even though California has experienced lopsided out-migration for decades, the financial blow has been cushioned by the kinds of people moving into the state: The newcomers were generally better educated and earned more money than those who left. Not now: That long-standing trend has reversed... The reversal, largely in response to the state's high taxes and soaring cost of living, has begun to damage California's overall economy. And, by cutting into tax revenues, has delivered punishing blows to state and local governments. State budget analysts recently projected a record $68 billion deficit in the next fiscal year because of a 25% drop in personal income tax collection in 2023. Some city, county and other local taxing authorities, particularly in the San Francisco Bay Area, have also recorded revenue declines. With investors and high-income taxpayers receiving substantial compensation in the form of stocks, last year's sluggish stock market accounted for a major share of the decline in state income tax revenues. So did layoffs and financial weakness in the tech sector. But rising unemployment in the state and the growing flight of professionals, business operators and others making good salaries were also notable contributors. And those factors will be harder to reverse, at least in the foreseeable future. "There's a price to pay for the movement of middle- and upper-income people and corporations," said Joel Kotkin, a fellow at Chapman University who has researched the flight from California and the resulting threat to the state's fiscal outlook. "People who are leaving are taking their tax dollars with them." The accelerating exodus from California in recent years, of both companies and people, has been well documented. The pandemic-induced rise in remote work, inflated housing prices and changing social conditions have spurred more Californians to pull up stakes... Moody's Analytics economist Mark Zandi analyzed moves in and out of California for The Times using Equifax credit data, to zero in on the age of the movers. He found that since the pandemic in early 2020, California has lost residents in every age group, but by a significant margin the biggest net out-migration came from those 35 to 44 years old. "This is probably motivated by the severe housing affordability crisis in California," Zandi said. "It's all but impossible for them to become homeowners in the state." Eric McGhee, a senior fellow at the Public Policy Institute of California, who has written about demographic trends in migration, thinks the increased loss of higher-educated Californians to other states in recent years can be traced in significant part to the rise of remote work since the pandemic. As more employers call workers back to the office, and the share of fully remote work appears to have settled at around 10% of all employees, McGhee expects the net out-migration from California to slow... Even if the outflow of residents reverts to pre-pandemic levels, the broader economic climate doesn't bode well for the state's budget and economic outlook, at least in the immediate future. The U.S. economy is slowing, and California's economy is decelerating faster than the nation's, with the state's unemployment rate, most recently at 4.8%, already a full point higher than nationwide. The article clarifies that "it's not just the sheer numbers of people who have left. What's different is that in each of the prior two years, more than 250,000 Californians with at least a bachelor's degree moved out, while an average of 175,000 college graduates from other states settled in California, according to an analysis of census data by William Frey, a demographer at the Brookings Institution. In prior periods over the last two decades, that balance was about even or slightly in California's favor." And besides billionaires, "There's been a broader exodus of ordinary Californians in the upper-income spectrum as well. In the tax filing years 2020 and 2021, the average gross income of taxpayers who had moved from California to another state was about $137,000. That was up from $75,000 in 2015 and 2016, according to migration and personal income data from the Internal Revenue Service." Read more of this story at Slashdot. | | 'Aquaman 2' Has Made Just 12% of What 'Aquaman 1' Earned Dec 31st 2023, 21:10, by EditorDavid Forbes writes: "I am not sure there could have been a more ignominious end to the DCEU." Aquaman 2 opened with $27.7 million domestically, well under half the $67.8 million opening for the original Aquaman. But it's the overall box office totals that are especially dire, as the film has made just over $138.5 million worldwide. That is about 12% of Aquaman 1's final total of $1.1 billion in 2018, where it is the DCEU's highest grossing entry. The counter to this is that it perhaps is too soon to run these numbers, as it just came out right? Well, a few extra factors to consider. It is already out in a ton of major markets, so there are relatively few potential surges that can still happen outside places like Korea and New Zealand, which can only add so much. Most importantly Aquaman 2 has already launched in China, where it made $30 million in its opening, again, far below the original's opening at $93 million there, doing even worse there than domestically, in context. Aquaman 1 went on to make $292 million in China, a figure Aquaman 2 will not come within a mile of. Next, what DC, and many blockbusters, have been doing lately are these incredibly short theatrical windows, so the clock is ticking quickly... Of course this is not exclusive to DC, as we have an extremely direct comparison over at Marvel with The Marvels, which at a $205.6 million global gross, the final figure, that is 18% of Captain Marvel's $1.13 billion total. Aquaman 2 has the advantage of being a true sequel, not a team-up piece from other TV shows you theoretically needed to watch beforehand, but it also has the disadvantage of being the last dying gasp of the DCEU coming after a string of other high profile box office failures from Shazam 2 to Blue Beetle. There was really no way it was going to avoid its fate, even if it did review well (which it didn't, as at 35% on Rotten Tomatoes, it's one of the DCEU's lowest rated films). Read more of this story at Slashdot. | | Is the Internet About to Get Weird Again? Dec 31st 2023, 18:34, by EditorDavid Long-time tech entrepreneur Anil Dash predicts a big shift in the digital landscape in 2024. And "regular internet users — not just the world's tech tycoons — may be the ones who decide how it goes." The first thing to understand about this new era of the internet is that power is, undoubtedly, shifting. For example, regulators are now part of the story — an ironic shift for anyone who was around in the dot com days. In the E.U., tech giants like Apple are being forced to hold their noses and embrace mandated changes like opening up their devices to allow alternate app stores to provide apps to consumers. This could be good news, increasing consumer choice and possibly enabling different business models — how about mobile games that aren't constantly pestering gamers for in-app purchases? Back in the U.S., a shocking judgment in Epic Games' (that's the Fortnite folks') lawsuit against Google leaves us with the promise that Android phones might open up in a similar way. That's not just good news for the billions of people who own smartphones. It's part of a sea change for the coders and designers who build the apps, sites, and games we all use. For an entire generation, the imagination of people making the web has been hemmed in by the control of a handful of giant companies that have had enormous control over things like search results, or app stores, or ad platforms, or payment systems. Going back to the more free-for-all nature of the Nineties internet could mean we see a proliferation of unexpected, strange new products and services. Back then, a lot of technology was created by local communities or people with a shared interest, and it was as likely that cool things would be invented by universities and non-profits and eccentric lone creators as they were to be made by giant corporations.... In that era, people could even make their own little social networks, so the conversations and content you found on an online forum or discussion were as likely to have been hosted by the efforts of one lone creator than to have come from some giant corporate conglomerate. It was a more democratized internet, and while the world can't return to that level of simplicity, we're seeing signs of a modern revisiting of some of those ideas. Dash's article (published in Rolling Stone) ends with examples of "people who had been quietly keeping the spirit of the human, personal, creative internet alive...seeing a resurgence now that the web is up for grabs again. " Digital artist Everest Pipkin The School for Poetic Computation (which Dash describes as "an eccentric, deeply charming, self-organized school for people who want to combine art and technology and a social conscience.") Mask On Zone, "a collaboration with the artist and coder Ritu Ghiya, which gives demonstrators and protesters in-context guidance on how to avoid surveillance." There's projects and tools from makers like Stefan Bohacek, Darius Kazemi, and Elan Kiderman Ullendorff (including Youtune ("a stream of relatively unviewed original songs posted to YouTube.") Dash concludes that "We're seeing the biggest return to that human-run, personal-scale web that we've witnessed since the turn of the millennium, with enough momentum that it's likely that 2024 is the first year since then that many people have the experience of making a new connection or seeing something go viral on a platform that's being run by a regular person instead of a commercial entity. "It's going to make a lot of new things possible..." A big thank-you for submitting the article to long-time Slashdot reader, DrunkenTerror. Read more of this story at Slashdot. | | Source-Based Gentoo Linux Goes Binary Dec 31st 2023, 17:34, by EditorDavid While Gentoo Linux is best-known as source-based Linux distribution, "our package manager, Portage, already for years also has support for binary packages," according to its web page. It notes that source- and binary-based package installations can be freely mixed. But now... To speed up working with slow hardware and for overall convenience, we're now also offering binary packages for download and direct installation! For most architectures, this is limited to the core system and weekly updates — not so for amd64 and arm64 however. There we've got a stunning >20 GByte of packages on our mirrors, from LibreOffice to KDE Plasma and from Gnome to Docker. Gentoo stable, updated daily. Enjoy! "We have a rather neat binary package guide on our Wiki that goes into much more detail..." the announcement points out. The packages are cryptographically signed with the same key as the stages. Thanks to Heraklit (Slashdot reader #29,346) for sharing the news. Read more of this story at Slashdot. | | How 'Digital Twin' Technology Is Revolutionizing the Auto Industry Dec 31st 2023, 16:34, by EditorDavid "Digital twin technology is one of the most significant disruptors of global manufacturing seen this century," argues Motor Trend, "and the automobile industry is embracing it in a big way." Roughly three-quarters of auto manufacturers are using digital twins as part of their vehicle development process, evolving not only how they design and develop new cars but also the way they monitor them, fix them, and even build them... Nvidia, best known for its consumer graphics cards, also has a digital twin solution, called Omniverse, which manufacturers such as Mercedes-Benz are using to design their manufacturing processes. "Their factory planners now have every single element in the factory that they can then put in that virtual digital twin first, lay it all out, and then operate it," Danny Shapiro, VP of automotive at Nvidia said. At that point, those planners can run the entire manufacturing process virtually, ensuring every conveyor feeds the next step in the process, identifying and addressing factory floor headaches long before production begins... Software developers can run their solutions within digital twins. That includes the code at the lowest level, basic stuff that controls ignition timing within the engine for example, all the way up to the highest level, like touchscreens responding to user inputs. "We're not just simulating the operation outside the car, but the user experience," Nvidia's Shapiro said. "We can simulate and basically run the real software that would be running in that car and display it on the screens." By bringing all these systems together virtually, developers can find and solve issues earlier, preventing costly development delays or, worse yet, buggy releases... Using unique identifiers, manufacturers can effectively create internal digital copies of vehicles that have been produced. Those copies can be used for ongoing tests and verifications, helping to anticipate things like required maintenance or susceptibility to part failures. By using telematics, in-car services that remotely communicate a car's status back to the manufacturer in real-time, these digital twins can be updated to match the real thing. "By monitoring tire health, tire grip, vehicle weight distribution, and other critical parameters, engineers can anticipate potential problems and schedule maintenance proactively, reducing downtime and extending the vehicle's lifespan," Tactile Mobility's Tzur said. Read more of this story at Slashdot. | |
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